Psychiatric NeuroImaging
The Centre for Neuroimaging Sciences (CNS) is a joint venture of the King's College London Institute of Psychiatry (IoP) and the South London and Maudsley NHS Trust (SLAM). Completed in early 2004, the centre provides, under one roof, an interdisciplinary research environment that combines the development of contemporary, high resolution structural, functional and metabolic mapping techniques, with expertise in the definition, diagnosis and treatment of neurological and psychiatric disorders.

Philosophy of the CNS
The CNS aims (a) to provide a comprehensive and world-class neuroradiological service to users within SLAM, and (b) to perform world-class research into psychiatric and neurological disorders, with a particular remit to study normal and abnormal development (c) to translate the use of such contemporary neuroimaging techniques from the research to the clinical domain. It is co-directed by Dr Ginny Ng from SLAM, and Prof Steve Williams from the IoP.

Clinical Facilities
The clinical Neuroimaging Department, situated at the Maudsley Hospital, is part of the Specialist Services Directorate of SLAM. The Department currently provides a full range of neuroradiographic imaging services, including Plain Radiography, Computerised Tomography (CT), and Magnetic Resonance Imaging (MRI). These imaging services are primarily provided for psychiatric clients from the South London & Maudsley NHS Trust Hospitals, but also for a substantial number of specialist, psychiatric and neurosciences referrals regionally from the South East of England and nationally, as well as a small number of clients from secure units and Her Majesty's prisons. A limited negotiated access to colleagues from both King's College Hospital and the Guy's, King's & St. Thomas' School of Medicine (GKT) also exists.

Research Facilities
For research studies, the CNS houses a dedicated GE 3T Excite II MRI scanner (which is also made available for clinical and advanced clinical scanning, where appropriate). Additionally, there is a GE SIGNA 1.5T neuro-optimised MR system housed in the adjacent Mapother House MR Unit. Both machines (along with the clinical 1.5T scanner) are capable of performing functional, spectroscopic, anatomical and pathological mapping techniques.

Post processing support is provided by the Brain Image Analysis Unit of the CNS. Over the past ten years, the BIAU has focussed mainly on the application of nonparametric (permutation-based) inferential procedures to MR analysis. A growing interest is the application of multidimensional wavelet analysis to MR data and the development of real-time fMRI analysis methodology running on Windows-based environments and portable PC systems. The unit has developed a number of software suites for automated MR analysis at single subject and group level which have been used in a large number of psychiatric and neurological investigations.

Current research projects span neurodegeneration, epilepsy, stroke, psychosis, affective disorders, developmental disorders, and normal brain function, using a battery of neuroimaging techniques which include perfusion, diffusion, functional and structural imaging. Our overall long-term objective is to translate our on-going pre-clinical developments in neuroimaging to the clinic, improving diagnosis and treatment of all these diseases.

Kings College London

Institute of Psychiatry

SLAM
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